Pain-Relieving Raw White Crystal Or Powder Phenacetin / Acetophenetidin
Melting point: 133-136 °C(lit.)
Boiling point: 132 °C / 4mmHg
Flash point: 2℃
storage temp. 2-8°C
Water Solubility 0.076 g/100 mL
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
Phenacetin is a human carcinogen based on sufficient evidence of carcinogenicity studies in experimental animals. In an 18-month carcinogenicity study, dietary administration of 2.5% phenacetin induced renal cell carcinomas of the renal pelvis and transitional cell carcinomas of the urinary bladder in rats, the tumor incidence in males being greater than in females. In another long-term carcinogenicity study, dietary administration of 0.535% phenacetin for 117 weeks induced renal pelvic tumors in male rats. In B6C3F1 mice of each sex maintained on a diet containing 1.25% or 0.6% phenacetin for 96 weeks, a dose-related induction of renal tumors was observed in male mice, and urinary bladder proliferative lesions developed in mice of either sex fed 1.25% phenacetin.
|Characters||A white or almost white crystalline powder||A white crystalline powder|
|Identification||Infrared absorption spectrum of the substance is same as that of Lidocaine Intermediate CRS||Conforms|
|Clarity and color of the solution||Clear and colorless≤Y6||Conforms|
|PH||Dissolve 2.0g in water and dilute to 20ml ph 3.5~5.5||4.3|
|Optical rotation||4%(W/V)Water solution +135°~+150°||+140°|
|Bacterial endotoxins||≤0.5 CFU/g||<0.5 CFU/g0.5 CFU/g|
|B of Lidocaine≤5.0%||5.0|
|Conclusion||The specification conform with enterprise standard|
Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics. Phenacetin also was once used as a stabilizer for hydrogen peroxide in hair-bleaching preparations.
Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,
low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic
effect. Because the enzyme inhibitor make phenacetins-Acetate not be converted into paracetamol, still showed obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The mild phenacetins-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.